Limitations to Python Support

Features Not Supported in MATLAB^®
Closing the Python^® interpreter while running MATLAB with in-process execution mode.
Saving (serializing) Python objects into a MAT-file.
Passing Python objects or keyword arguments created by `pyargs` as key arguments to the MATLAB `dictionary` function or as input to the `keyMatch` function.
Interactive Python help (calling `py.help` without input arguments).
Accessing static properties of a Python class.
MATLAB `isa` function does not recognize virtual inheritance.
MATLAB class inheritance from a Python class.
Customized (dynamic) attribute access.
Nested Python classes.
Modules that start MATLAB in a separate process, for example, the `multiprocessing` module.
Modules that read `sys.argv`, the command-line arguments passed to a Python script, for example, `Tkinter`.
Dynamically generated Python classes.
Dynamically attaching new object attributes. Instead, use `py.setattr`.
Class names or other identifiers starting with an underscore (`_`) character. Instead, use the Python `py.getattr` and `py.setattr` functions.
Python modules generated by the MATLAB Compiler SDK™ product.
Python code using Cocoa (AppKit) for user interfaces on macOS platforms.
The size of variables passed between Python and MATLAB is limited to 2 GB when you call a Python function out-of-process. This limit applies to the data plus supporting information passed between the processes.

Limitations to `pyrun` and `pyrunfile` Functions

Python classes defined using pyrun or pyrunfile cannot be modified if you return an instance of the class to MATLAB. If you need to change class definitions, restart the interpreter session:

terminate(pyenv)
pyenv(ExecutionMode="OutOfProcess")

Alternatively, restart MATLAB for "InProcess".

The pyrun and pyrunfile functions do not support classes with local variables that are initialized by other local variables through methods. For such usage, create a module and access it using the py. prefix.

Unsupported MATLAB Types

These MATLAB types are not supported in Python.

Multidimensional char or cell arrays
Sparse arrays
struct arrays
categorical types
containers.Map types
MATLAB objects
matlab.metadata.Class (py.class)