Simulation of tissue drug concentration profile with Kp values
4 次查看(过去 30 天)
显示 更早的评论
I'm trying to develop the compartment model to simulate a lung concentration time profile of unchanged and metabolized drugs with tissue Kp value in simbiology app. This is because these drugs have very high lung Kp values (i.e. 100). I tried that lung concentration of unchanged drugs equals to the product of peripheral concentration and the lung Kp with repeated assginment, but I was not able to cope with this equation and the differential equation for the metabolism of unchanged drugs to metabolites in lung. How can I incorporate Kp values for the simulation of tissue concentration?
0 个评论
采纳的回答
Arthur Goldsipe
2021-10-14
If you are looking for an example of how to incorporate tissue partition coefficients into a PBPK model, then perhaps you can use the following SimBiology model as an example: Generic SimBiology PBPK model
更多回答(0 个)
社区
更多回答在 SimBiology Community
另请参阅
类别
在 Help Center 和 File Exchange 中查找有关 Biotech and Pharmaceutical 的更多信息
Community Treasure Hunt
Find the treasures in MATLAB Central and discover how the community can help you!
Start Hunting!