搜索
Hi! I'm new to pk modeling and Matlab. Can someone guide me through how to conduct population pk modeling based on pk parameters from non-human primate studies? Much thanks!!!!
The title is resonably non-descript, but I can explain it easily:
Say I have an initial Emax model:
v = emax1*[G]^n1/(ec501^n1+[G]^n1)
And I want to place v inside of a second Emax model:
y = emax2*v^n2/(ex502^n2+v^n2)
Currently, I have the full function of v inside y, twice, it's very long and whilst I only need to get it correct once, for readability in the future I'd rather have it in form #2. I've played around with non-constant parameters but I need the steady state to be v, not the rate rule, and I haven't worked out how to make a parameter shift to a form like v, as an observation might.
Are there any recommended solutions or do I simply need to keep with having v fully expressed in y?
Thank you,
Dan
Hi All,
I'm currently attempting to implement a Hodgkin-Huxley-type model of membrane potential, ideally I would like a species that represents the membrane potential as its own distinct entity, so as the reference elsewhere. I've currently established a molarity-based work around but it would be great if I could set the units for the species as millivolt, but that throws an error.
Is there an established way to do this? I imagine I'm not the first person to be trying to model a voltage-gated ion channel!
Thank you for your help.
Share your fun photos in the comments!
Here's a MATLAB class I wrote that leverages the MATLAB Central Interface for MATLAB toolbox, which in turn uses the publicy available Community API. Using this class, I've created a few Favorites that show me what's going on in MATLAB Central - without having to leave MATLAB 🙂
The class has a few convenient queries:
- Results for the last 7 days
- Results for the last 30 days
- Results for the current month
- Results for today
And supporting a bunch of different content scopes:
- All MATLAB Central
- MATLAB Answers
- Blogs
- Cody
- Contests
- File Exchange
- Exclude Answers content
The results are displayed in the command window (which worked best for me) and link to each post. Here's what that looks like for this command
>> CommunityFeed.thisMonth("app designer", CommunityFeed.Scope.ExcludeAnswers)
Let me know if you find this class useful and feel free to suggest changes.
Hello,
I've looked around and I haven't found anything obvious about this, but is it possible to link to species/reactions, graphically, in a non-mass transfer sense? I have areas in my model where it would conceptually make sense to be able to see that species or reactions are linked, but if I link them in the standard way it demands that it be involved in the stoichiometry.
Perhaps some kind of dotted line, or similar?
Thank you, best regards,
Dan
New Cheat Sheet Alert!
Level up your data organization and access skills in MATLAB with our latest cheat sheet! Download the full cheat sheet on MATLAB GitHub for Students here.
Wait for Walter, the rest of us are mere users.
MATLAB Training
MATLAB Training
Mathworks tech support
Stand Back. I'm going to try MATLAB.
Embarassed by Walter Roberson
I use MATLAB.
MATLAB Reloaded
MATLAB Men
MATLAB rule!
So true.
