How to load very large trajectory file

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I have a very large simulation trajectory file with 40000 frames and each frame has coordinates rx,ry,rz for almost 300 particles.I want to use only a frame at time and move to second frame in series of calculation like radial distirbution function.How should I load and read the trajectory file frame by frame? Can anyone suggest me the procedure or should i proceed with normal commands like dlmread and fscan?

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