How to implement constraints (conditions) to the estimation of parameters by fitting?

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Luis B. Walter
Luis B. Walter 2024-6-7
评论： Luis B. Walter 2024-6-11
Hi to everyone!
How to implement in the Simbiology interface so that the estimated parameters in a fit satisfy a given condition? For example, estimate by a fit the values ​​of the kinetic constants k1 and k-1 for a serie of experimental data, which satisfy the value of the equilibrium constant Keq (Keq= k1/k-1) within a given interval, such as K= 10±2.
Thank you in advance!

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Jeremy Huard
Jeremy Huard 2024-6-7
Hi @Luis B. Walter,
one idea would be to actually estimate and , with and have be calculated in the model with an initial assignment .
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Jeremy Huard
Jeremy Huard 2024-6-10
Hi @Luis B. Walter,
Thanks for this input!
As of R2024a, SimBiology only supports bound constraints, both in the Model analyzer App and programmatically with sbiofit / fitProblem.
That said, if you want more general constraints, you could set up an optimization problem by writing the objective function and constraints using a SimFunction to simulate your SimBiology model and optimproblem to set up the optimization problem.
Best regards,
Jérémy

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