No, MATLAB/Simulink cannot directly run the 'xrun' command from Cadence.
However, if you wish to integrate Simulink models with Cadence tools which use the 'xrun' command for running mixed signal simulations in the context of HDLs then you can perform co-simulation with the HDL Verifier which provides the support for Cadence Xcelium or Incisive.
For more information on how to run a Simulink co-simulation session, refer to the following documentation links:
