How to detect lesions in diabetic retinopathy especially microaneurysm

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I was trying to detect lesions in DR. I tried to calculate using intensity values. But my output is like regional maximum. I don't know the correct method. Please can anyone help me with methods

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Image Analyst
Image Analyst 2015-8-25
We don't do complicated algorithm development here. I suggest you find similar methods in published papers here: http://www.visionbib.com/bibliography/contentsmedical.html#Medical%20Applications,%20CAT,%20MRI,%20Ultrasound,%20Heart%20Models,%20Brain%20Models

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