You can always write MATLAB code that loops through variable values and runs the Simulink model multiple times:
The best way to do this is to create variables for the two Constant block values. This lets you easily make modifications in your script:
C1 = 1;
C2 = 1;
simOut = sim('model', ... );
C1 = 5;
C2 = -42.675; % why not?
simOut = sim('model', ... );
... and so on.
- Sebastian