To do real-time filtering, you need the DSP System Toolbox. You probably also need specialised hardware. (I have no experience with the DSP System Toolbox, so I cannot help you with it.)
I seriously doubt that you could do a Savitzky-Golay filter in real time. Instead, save your raw signals and process them later. You will need to do a fft on your saved signals, determine the frequencies of the signals and the frequencies of the noise, then design a bandpass filter to eliminate the d-c offset and slow baseline drift on the low end, and noise at the high end. You cannot eliminate broadband noise with a frequency selective filter, so some noise will remain after the filtering process.
