You will need the Signal Processing Toolbox.
I would first do a fft on your data, to see if your signal can be separated from high-frequency noise. If so, an appropriately-designed lowpass discrete filter would probably work. (My filter design procedure is: How to design a lowpass filter for ocean wave data in Matlab?)
If you have broadband noise that cannot be effectively filtered, with your data, my first approach would be to use the sgolayfilt function to do Savitzky-Golay filtering on it.
All signal processing on actual data requires some experimentation, and the noisier the signal, the more experimentation will be necessary. Be prepared to spend some time processing your data.
