Calculating affine transformation using corresponding points

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Hello, I have a question about feature-based image registration process. I have two 3D images (volumes) with a set of N predefined corresponding points of [x,y,z,X,Y,Z] (where [x,y,z] and [X,Y,Z] are the coordinates of corresponding points in reference/imgR and target/imgT images, correspondingly). I am trying to align them based on these corresponding points using affine transformation.
Here are the steps I have gone through to register imgR and imgT volumes using 4 points:
  • Four sets of corresponding points are selected randomly.
  • Affine transformation matrix (T) is calculated using selected corresponding points (see below).
  • Target image is resampled based on the calculated T using MATLAB's built-in imwarp function.
This works okay but it is not so accurate. How can I use all of the corresponding points instead of 4 of them?

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