for i=20
R_1{i}= randsample('ACGT',1,true,[1 0 0 0]);
R_2{i}= randsample('ACGT',1,true,[0.5 0 0.5 0]);
R_3{i}= randsample('ACGT',1,true,[0.25 0.25 0.25 0.25]);
R_4{i}= randsample('ACGT',1,true,[0.5 0 0 0.5]);
R_5{i}= randsample('ACGT',1,true,[0 0 0 1]);
R_6{i}= randsample('ACGT',1,true,[0.5 0 0 0.5]);
R_7{i}= randsample('ACGT',1,true,[0.5 0 0.5 0]);
end