The nlinfit() function in the Statistics Toolbox does this type of fit. Here is a simple example that I wrote to help another poster:
% Here is an example of using nlinfit(). For simplicity, none of
% of the fitted parameters are actually nonlinear!
% Define the data to be fit
x=(0:1:10)'; % Explanatory variable
y = 5 + 3*x + 7*x.^2; % Response variable (if response were perfect)
y = y + 2*randn((size(x)));% Add some noise to response variable
% Define function that will be used to fit data
% (F is a vector of fitting parameters)
f = @(F,x) F(1) + F(2).*x + F(3).*x.^2;
F_fitted = nlinfit(x,y,f,[1 1 1]);
% Display fitted coefficients
disp(['F = ',num2str(F_fitted)])
% Plot the data and fit
figure(1)
plot(x,y,'*',x,f(F_fitted,x),'g');
legend('data','fit')
