Hi Karthik,
When using GPIB interface, you might want to make sure that your instrument is configured to use GPIB interface and that it has a unique primary address. You can change the address from the instrument's front panel such that it is unique (different from other instrument's primary address).
Since you plan to use the VXIPnP driver, you need to download and install the VXIPnP driver from R&S website. Once you install the driver, you can confirm the installation by using the instrhwinfo('vxipnp') command. From there on, you might want to follow the Using VXIplug&play driver section of the online documentation.
Hope this helps,
-Ankit