How to do Bayesian Parameter Estimation using Optimization in Simbiology

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Andy 2017-6-27

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https://ww2.mathworks.cn/matlabcentral/answers/346462-how-to-do-bayesian-parameter-estimation-using-optimization-in-simbiology

回答： Andy 2017-7-2

Hello Matlab Community, I have a one-compartment pharmacokinetic model with the following parameters: Ka=0.8 (1/Hour), CL=26 (Liters/Hour), Vd=947 (Liters).

I am administering is 10mg every 24-hours 14-days = 336-hours.

What I would like to do is to add in a trough plasma concentration at 14-days of 40ng/mL.

What I would like to see if Simbiology can do is to estimate the Clearance Rate (CL) alone by keeping the Ka and Vd fixed at time=336hours and concentration=40ng/mL.

I can do this manually, by adjusting the Clearance Rate parameter, but I was looking to see if this may be automated to fit the data-point or concentration at time point 336hours of 40ng/mL. Thus, time=336, concentration=40ng/mL.

Thanks for your help.

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Answer 1

Arthur Goldsipe 2017-6-28

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The SimBiology documentation describes different ways to estimate parameters in a model. Does that help?

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Answer 2

Andy 2017-7-2

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Hi Arthur, Of course this helps. I suppose I will run the fit data task and then I may convert that process to a matlab script. Thanks for that. I am glad to have these Matlab Answers pages.

Thanks again.