The best approach is to use Fast Restart simulation: https://www.mathworks.com/help/simulink/ug/fast-restart-workflow.html
Fast restart will let you run simulations repeatedly without recompiling, as long as the variables you're changing do not affect the model in any way. For example, you can change tunable parameters, inputs, etc. but not structural things such as sample times, data types, dimensions, etc.
To do this from the command line, you can just do:
for idx = 1:100
myParams = externalFunction(idx);
simout = sim('modelName','FastRestart','on');
end
- Sebastian
