You do not specify what kind of matrix you have, so I will assume that it is a cell array (as a numeric array would not hold string/char data). This code should get you started, please experiment and adapt as required:
P = '.'; % directory path
C = 65x10 cell array
for k = 2:size(C,2)
N = sprintf('column_%d.csv',k);
[fid,msg] = fopen(fullfile(P,N),'wt');
assert(fid>=3,msg)
fprintf(fid,'%s,%s\n',C{1,[1,k]});
tmp = C(2:end,[1,k]).';
fprintf(fid,'%s,%d\n',tmp{:});
fclose(fid);
end
