You have to pass a function handle as the objective function, but it does not have to be an anonymous function. You can pass the handle to a function that does extensive computation based on the inputs. The only requirement is that the output has to be a scalar.
If you are trying to minimize two distinct things simultaneously then you either need to decide their relative weighting to combine them into a scalar, or else you need to use gamultiobj() to find pareto fronts.
