You should avoid loading data inside an objective function, as that function will be called many times. You should instead http://www.mathworks.com/help/matlab/math/parameterizing-functions.html parameterize
That could include,
filestruct = load('file.mat', 'file');
file = filestruct.file;
for li = 1 : whatever
func{i} = @(x) Objfunc(x, file(:,li));
end
parfor li = 1 : whatever
patternsearch(func{i}, ....)
end
or you could
filestruct = load('file.mat', 'file');
file = filestruct.file;
parfor li = 1 : whatever
patternsearch( @(x) Objfunc(x, file(:,li)), ...)
end
