If you want to differentiate them using the Symbolic Math Toolbox, start with:
syms t
x(t) = 5*t*sin(4*t)
y(t) = 12*t + 200*t^3/3
z(t) = 5*t*cos(4*t)
MATLAB does not recognise implicit multiplication, so you need to supply the multiplication operators. (I did that for you here.)