Full distribution for 'b' coefficient when using coxphfit

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Aviram Shemen
Aviram Shemen 2020-8-16
评论： Aviram Shemen 2020-8-19
I'm using coxphfit function. But you only get the HR as exp(b) and the corresponding SE. I want to know if there is a way to get the full distribution from which b and SE were calculated?
Thanks.

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the cyclist
the cyclist 2020-8-16
I have a few thoughts.
When you say "usually you get ...", do you mean from some other software package, specifically?
Are you calling coxphfit with all the outputs?
[b,logl,H,stats] = coxphfit()
Is that helpful?
Have you seen this documentation page that lists a lot of details about what MATLAB is doing (in addition to the documentation for coxphfit itself).
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the cyclist
the cyclist 2020-8-18
To be clear ... I don't actually think that a gaussian is used in any explicit way in the algorithm.
The coefficent(s) b are found by an iterative process that maximizes the partial likelihood function. I can see that the code uses an optimization method involving trust regions, and I am just speculating that that method might implicitly make assumptions about the quadratic nature of the curvature, and maybe that is equivalent to a gaussian assumption for b. I think one would need to actually understand that optimization method -- as opposed to the model itself -- to really know what is going on under the hood.

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