Why are you using uint16 when you have a negative number?????
Anyway,...
S = -5;
Cw1=dec2bin(typecast(int16(S),'uint16'),15)
S_recovered = bin2dec(Cw1)
maxUint16 = intmax('uint16')
maxInt16 = intmax('int16')
if S_recovered > maxInt16
S_recovered = int16(S_recovered - double(maxUint16) - 1)
end
S_recovered will be -5 as a signed 16 bit integer, which is what I assume you want.
