Using a mask with a Different matrix size as target image to obtain image

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I have a known Mask as a 240x240 Double. I usually use this mask against the same matrix size image but I need a way to convert this to use it against an image with a matrix size 448x448 uint16.
The code i usually use is
T2FS=dicomread(T2FSa{1});
T2FS(~mask)=NaN;
imagesc(T2FS); %shows the mask
avgSig=mean(T2FS(mask));
but the mask and the image T2FS aren't the same image matrix size. Any help would be greatly appreciated.
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Image Analyst
Image Analyst 2013-4-17
So where in the larger image do you want to place your mask? Or do you want to scale it with imresize() so that it's the same size as your image?

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