The short answer is "no".
The long answer is that there might be a difference on where the MATLAB application is installed and where e.g. data files are read or written. Note that some customer install MATLAB somewhere on the network, like the same machine / server where the FLEXnet license server runs. But this is just an option, not a need. You can also install locally and only the license manager is on the server.
Also one factor that could be seen is that the startup time is slower when there is a network administered license. But this is actually something that likely can be addressed with the help of installation support.
