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The study of the dynamics of the discrete Klein - Gordon equation (DKG) with friction is given by the equation :
above equation, W describes the potential function :
The objective of this simulation is to model the dynamics of a segment of DNA under thermal fluctuations with fixed boundaries using a modified discrete Klein-Gordon equation. The model incorporates elasticity, nonlinearity, and damping to provide insights into the mechanical behavior of DNA under various conditions.
% Parameters
numBases = 200; % Number of base pairs, representing a segment of DNA
kappa = 0.1; % Elasticity constant
omegaD = 0.2; % Frequency term
beta = 0.05; % Nonlinearity coefficient
delta = 0.01; % Damping coefficient
  • Position: Random initial perturbations between 0.01 and 0.02 to simulate the thermal fluctuations at the start.
  • Velocity: All bases start from rest, assuming no initial movement except for the thermal perturbations.
% Random initial perturbations to simulate thermal fluctuations
initialPositions = 0.01 + (0.02-0.01).*rand(numBases,1);
initialVelocities = zeros(numBases,1); % Assuming initial rest state
The simulation uses fixed ends to model the DNA segment being anchored at both ends, which is typical in experimental setups for studying DNA mechanics. The equations of motion for each base are derived from a modified discrete Klein-Gordon equation with the inclusion of damping:
% Define the differential equations
dt = 0.05; % Time step
tmax = 50; % Maximum time
tspan = 0:dt:tmax; % Time vector
x = zeros(numBases, length(tspan)); % Displacement matrix
x(:,1) = initialPositions; % Initial positions
% Velocity-Verlet algorithm for numerical integration
for i = 2:length(tspan)
% Compute acceleration for internal bases
acceleration = zeros(numBases,1);
for n = 2:numBases-1
acceleration(n) = kappa * (x(n+1, i-1) - 2 * x(n, i-1) + x(n-1, i-1)) ...
- delta * initialVelocities(n) - omegaD^2 * (x(n, i-1) - beta * x(n, i-1)^3);
end
% positions for internal bases
x(2:numBases-1, i) = x(2:numBases-1, i-1) + dt * initialVelocities(2:numBases-1) ...
+ 0.5 * dt^2 * acceleration(2:numBases-1);
% velocities using new accelerations
newAcceleration = zeros(numBases,1);
for n = 2:numBases-1
newAcceleration(n) = kappa * (x(n+1, i) - 2 * x(n, i) + x(n-1, i)) ...
- delta * initialVelocities(n) - omegaD^2 * (x(n, i) - beta * x(n, i)^3);
end
initialVelocities(2:numBases-1) = initialVelocities(2:numBases-1) + 0.5 * dt * (acceleration(2:numBases-1) + newAcceleration(2:numBases-1));
end
% Visualization of displacement over time for each base pair
figure;
hold on;
for n = 2:numBases-1
plot(tspan, x(n, :));
end
xlabel('Time');
ylabel('Displacement');
legend(arrayfun(@(n) ['Base ' num2str(n)], 2:numBases-1, 'UniformOutput', false));
title('Displacement of DNA Bases Over Time');
hold off;
The results are visualized using a plot that shows the displacements of each base over time . Key observations from the simulation include :
  • Wave Propagation: The initial perturbations lead to wave-like dynamics along the segment, with visible propagation and reflection at the boundaries.
  • Damping Effects: The inclusion of damping leads to a gradual reduction in the amplitude of the oscillations, indicating energy dissipation over time.
  • Nonlinear Behavior: The nonlinear term influences the response, potentially stabilizing the system against large displacements or leading to complex dynamic patterns.
% 3D plot for displacement
figure;
[X, T] = meshgrid(1:numBases, tspan);
surf(X', T', x);
xlabel('Base Pair');
ylabel('Time');
zlabel('Displacement');
title('3D View of DNA Base Displacements');
colormap('jet');
shading interp;
colorbar; % Adds a color bar to indicate displacement magnitude
% Snapshot visualization at a specific time
snapshotTime = 40; % Desired time for the snapshot
[~, snapshotIndex] = min(abs(tspan - snapshotTime)); % Find closest index
snapshotSolution = x(:, snapshotIndex); % Extract displacement at the snapshot time
% Plotting the snapshot
figure;
stem(1:numBases, snapshotSolution, 'filled'); % Discrete plot using stem
title(sprintf('DNA Model Displacement at t = %d seconds', snapshotTime));
xlabel('Base Pair Index');
ylabel('Displacement');
% Time vector for detailed sampling
tDetailed = 0:0.5:50; % Detailed time steps
% Initialize an empty array to hold the data
data = [];
% Generate the data for 3D plotting
for i = 1:numBases
% Interpolate to get detailed solution data for each base pair
detailedSolution = interp1(tspan, x(i, :), tDetailed);
% Concatenate the current base pair's data to the main data array
data = [data; repmat(i, length(tDetailed), 1), tDetailed', detailedSolution'];
end
% 3D Plot
figure;
scatter3(data(:,1), data(:,2), data(:,3), 10, data(:,3), 'filled');
xlabel('Base Pair');
ylabel('Time');
zlabel('Displacement');
title('3D Plot of DNA Base Pair Displacements Over Time');
colorbar; % Adds a color bar to indicate displacement magnitude
Updating some of my educational Livescripts to 2024a, really love the new "define a function anywhere" feature, and have a "new" idea for improving Livescripts -- support "hidden" code blocks similar to the Jupyter Notebooks functionality.
For example, I often create "complicated" plots with a bunch of ancillary items and I don't want this code exposed to the reader by default, as it might confuse the reader. For example, consider a Livescript that might read like this:
-----
Noting the similar structure of these two mappings, let's now write a function that simply maps from some domain to some other domain using change of variable.
function x = ChangeOfVariable( x, from_domain, to_domain )
x = x - from_domain(1);
x = x * ( ( to_domain(2) - to_domain(1) ) / ( from_domain(2) - from_domain(1) ) );
x = x + to_domain(1);
end
Let's see this function in action
% HIDE CELL
clear
close all
from_domain = [-1, 1];
to_domain = [2, 7];
from_values = [-1, -0.5, 0, 0.5, 1];
to_values = ChangeOfVariable( from_values, from_domain, to_domain )
to_values = 1×5
2.0000 3.2500 4.5000 5.7500 7.0000
We can plot the values of from_values and to_values, showing how they're connected to each other:
% HIDE CELL
figure
hold on
for n = 1 : 5
plot( [from_values(n) to_values(n)], [1 0], Color="k", LineWidth=1 )
end
ax = gca;
ax.YTick = [];
ax.XLim = [ min( [from_domain, to_domain] ) - 1, max( [from_domain, to_domain] ) + 1 ];
ax.YLim = [-0.5, 1.5];
ax.XGrid = "on";
scatter( from_values, ones( 5, 1 ), Marker="s", MarkerFaceColor="flat", MarkerEdgeColor="k", SizeData=120, LineWidth=1, SeriesIndex=1 )
text( mean( from_domain ), 1.25, "$\xi$", Interpreter="latex", HorizontalAlignment="center", VerticalAlignment="middle" )
scatter( to_values, zeros( 5, 1 ), Marker="o", MarkerFaceColor="flat", MarkerEdgeColor="k", SizeData=120, LineWidth=1, SeriesIndex=2 )
text( mean( to_domain ), -0.25, "$x$", Interpreter="latex", HorizontalAlignment="center", VerticalAlignment="middle" )
scaled_arrow( ax, [mean( [from_domain(1), to_domain(1) ] ) - 1, 0.5], ( 1 - 0 ) / ( from_domain(1) - to_domain(1) ), 1 )
scaled_arrow( ax, [mean( [from_domain(end), to_domain(end)] ) + 1, 0.5], ( 1 - 0 ) / ( from_domain(end) - to_domain(end) ), -1 )
text( mean( [from_domain(1), to_domain(1) ] ) - 1.5, 0.5, "$x(\xi)$", Interpreter="latex", HorizontalAlignment="center", VerticalAlignment="middle" )
text( mean( [from_domain(end), to_domain(end)] ) + 1.5, 0.5, "$\xi(x)$", Interpreter="latex", HorizontalAlignment="center", VerticalAlignment="middle" )
-----
Where scaled_arrow is some utility function I've defined elsewhere... See how a majority of the code is simply "drivel" to create the plot, clear and close? I'd like to be able to hide those cells so that it would look more like this:
-----
Noting the similar structure of these two mappings, let's now write a function that simply maps from some domain to some other domain using change of variable.
function x = ChangeOfVariable( x, from_domain, to_domain )
x = x - from_domain(1);
x = x * ( ( to_domain(2) - to_domain(1) ) / ( from_domain(2) - from_domain(1) ) );
x = x + to_domain(1);
end
Let's see this function in action
Show code cell
from_domain = [-1, 1];
to_domain = [2, 7];
from_values = [-1, -0.5, 0, 0.5, 1];
to_values = ChangeOfVariable( from_values, from_domain, to_domain )
to_values = 1×5
2.0000 3.2500 4.5000 5.7500 7.0000
We can plot the values of from_values and to_values, showing how they're connected to each other:
Show code cell
-----
Thoughts?
I recently had issues with code folding seeming to disappear and it turns out that I had unknowingly disabled the "show code folding margin" option by accident. Despite using MATLAB for several years, I had no idea this was an option, especially since there seemed to be no references to it in the code folding part of the "Preferences" menu.
It would be great if in the future, there was a warning that told you about this when you try enable/disable folding in the Preferences.
I am using 2023b by the way.
In the MATLAB editor, when clicking on a variable name, all the other instances of the variable name will be highlighted.
But this does not work for structure fields, which is a pity. Such feature would be quite often useful for me.
I show an illustration below, and compare it with Visual Studio Code that does it. ;-)
I am using MATLAB R2023a, sorry if it has been added to newer versions, but I didn't see it in the release notes.
As far as I know, the MATLAB Community (including Matlab Central and Mathworks' official GitHub repository) has always been a vibrant and diverse professional and amateur community of MATLAB users from various fields globally. Being a part of it myself, especially in recent years, I have not only benefited continuously from the community but also tried to give back by helping other users in need.
I am a senior MATLAB user from Shenzhen, China, and I have a deep passion for MATLAB, applying it in various scenarios. Due to the less than ideal job market in my current social environment, I am hoping to find a position for remote support work within the Matlab Community. I wonder if this is realistic. For instance, Mathworks has been open-sourcing many repositories in recent years, especially in the field of deep learning with typical applications across industries. I am eager to use the latest MATLAB features to implement state-of-the-art algorithms. Additionally, I occasionally contribute through GitHub issues and pull requests.
In conclusion, I am looking forward to the opportunity to formally join the Matlab Community in a remote support role, dedicating more energy to giving back to the community and making the world a better place! (If a Mathworks employer can contact me, all the better~)

Hello MathWorks Community,

I am excited to announce that I am currently working on a book project centered around Matrix Algebra, specifically designed for MATLAB users. This book aims to cater to undergraduate students in engineering, where Matrix Algebra serves as a foundational element.

Matrix Algebra is not only pivotal in understanding complex engineering concepts but also in applying these principles effectively in various technological solutions. MATLAB, renowned for its powerful computational capabilities, is an excellent tool to explore and implement these concepts, making it a perfect companion for this book.

As I embark on this journey to create a resource that bridges theoretical matrix algebra with practical MATLAB applications, I am looking for one or two knowledgeable individuals who have a firm grasp of both subjects. If you have experience in teaching or applying matrix algebra in engineering contexts and are familiar with MATLAB, your contribution could be invaluable.

Collaborators will help in shaping the content to ensure it is educational, engaging, and technically robust, making complex concepts accessible and applicable for students.

If you are interested in contributing to this project or know someone who might be, please reach out to discuss how we can work together to make this book a valuable resource for engineering students.

Thank you and looking forward to your participation!

I created an ellipse visualizer in #MATLAB using App Designer! To read more about it, and how it ties to the recent total solar eclipse, check out my latest blog post:
Github Repo of the app (you can open it on MATLAB Online!):
What's the weather like in your place?
I'm excited to share some valuable resources that I've found to be incredibly helpful for anyone looking to enhance their MATLAB skills. Whether you're just starting out, studying as a student, or are a seasoned professional, these guides and books offer a wealth of information to aid in your learning journey.
These materials are freely available and can be a great addition to your learning resources. They cover a wide range of topics and are designed to help users at all levels to improve their proficiency in MATLAB.
Happy learning and I hope you find these resources as useful as I have!
I found this link posted on Reddit.
https://workhunty.com/job-blog/where-is-the-best-place-to-be-a-programmer/Matlab/
Let S be the closed surface composed of the hemisphere and the base Let be the electric field defined by . Find the electric flux through S. (Hint: Divide S into two parts and calculate ).
% Define the limits of integration for the hemisphere S1
theta_lim = [-pi/2, pi/2];
phi_lim = [0, pi/2];
% Perform the double integration over the spherical surface of the hemisphere S1
% Define the electric flux function for the hemisphere S1
flux_function_S1 = @(theta, phi) 2 * sin(phi);
electric_flux_S1 = integral2(flux_function_S1, theta_lim(1), theta_lim(2), phi_lim(1), phi_lim(2));
% For the base of the hemisphere S2, the electric flux is 0 since the electric
% field has no z-component at the base
electric_flux_S2 = 0;
% Calculate the total electric flux through the closed surface S
total_electric_flux = electric_flux_S1 + electric_flux_S2;
% Display the flux calculations
disp(['Electric flux through the hemisphere S1: ', num2str(electric_flux_S1)]);
disp(['Electric flux through the base of the hemisphere S2: ', num2str(electric_flux_S2)]);
disp(['Total electric flux through the closed surface S: ', num2str(total_electric_flux)]);
% Parameters for the plot
radius = 1; % Radius of the hemisphere
% Create a meshgrid for theta and phi for the plot
[theta, phi] = meshgrid(linspace(theta_lim(1), theta_lim(2), 20), linspace(phi_lim(1), phi_lim(2), 20));
% Calculate Cartesian coordinates for the points on the hemisphere
x = radius * sin(phi) .* cos(theta);
y = radius * sin(phi) .* sin(theta);
z = radius * cos(phi);
% Define the electric field components
Ex = 2 * x;
Ey = 2 * y;
Ez = 2 * z;
% Plot the hemisphere
figure;
surf(x, y, z, 'FaceAlpha', 0.5, 'EdgeColor', 'none');
hold on;
% Plot the electric field vectors
quiver3(x, y, z, Ex, Ey, Ez, 'r');
% Plot the base of the hemisphere
[x_base, y_base] = meshgrid(linspace(-radius, radius, 20), linspace(-radius, radius, 20));
z_base = zeros(size(x_base));
surf(x_base, y_base, z_base, 'FaceColor', 'cyan', 'FaceAlpha', 0.3);
% Additional plot settings
colormap('cool');
axis equal;
grid on;
xlabel('X');
ylabel('Y');
zlabel('Z');
title('Hemisphere and Electric Field');
David
David
Last activity 2024-4-2

I feel like no one at UC San Diego knows this page, let alone this server, is still live. For the younger generation, this is what the whole internet used to look like :)
In short: support varying color in at least the plot, plot3, fplot, and fplot3 functions.
This has been a thing that's come up quite a few times, and includes questions/requests by users, workarounds by the community, and workarounds presented by MathWorks -- examples of each below. It's a feature that exists in Python's Matplotlib library and Sympy. Anyways, given that there are myriads of workarounds, it appears to be one of the most common requests for Matlab plots (Matlab's plotting is, IMO, one of the best features of the product), the request precedes the 21st century, and competitive tools provide the functionality, it would seem to me that this might be the next great feature for Matlab plotting.
I'm curious to get the rest of the community's thoughts... what's everyone else think about this?
---
User questions/requests
User-provided workarounds
MathWorks-provided workarounds
Hannah
Hannah
Last activity 2024-4-1

Although, I think I will only get to see a partial eclipse (April 8th!) from where I am at in the U.S. I will always have MATLAB to make my own solar eclipse. Just as good as the real thing.
Code (found on the @MATLAB instagram)
a=716;
v=255;
X=linspace(-10,10,a);
[~,r]=cart2pol(X,X');
colormap(gray.*[1 .78 .3]);
[t,g]=cart2pol(X+2.6,X'+1.4);
image(rescale(-1*(2*sin(t*10)+60*g.^.2),0,v))
hold on
h=exp(-(r-3)).*abs(ifft2(r.^-1.8.*cos(7*rand(a))));
h(r<3)=0;
image(v*ones(a),'AlphaData',rescale(h,0,1))
camva(3.8)
One of the privileges of working at MathWorks is that I get to hang out with some really amazing people. Steve Eddins, of ‘Steve on Image Processing’ fame is one of those people. He recently announced his retirement and before his final day, I got the chance to interview him. See what he had to say over at The MATLAB Blog The Steve Eddins Interview: 30 years of MathWorking
Before we begin, you will need to make sure you have 'sir_age_model.m' installed. Once you've downloaded this folder into your working directory, which can be located at your current folder. If you can see this file in your current folder, then it's safe to use it. If you choose to use MATLAB online or MATLAB Mobile, you may upload this to your MATLAB Drive.
This is the code for the SIR model stratified into 2 age groups (children and adults). For a detailed explanation of how to derive the force of infection by age group.
% Main script to run the SIR model simulation
% Initial state values
initial_state_values = [200000; 1; 0; 800000; 0; 0]; % [S1; I1; R1; S2; I2; R2]
% Parameters
parameters = [0.05; 7; 6; 1; 10; 1/5]; % [b; c_11; c_12; c_21; c_22; gamma]
% Time span for the simulation (3 months, with daily steps)
tspan = [0 90];
% Solve the ODE
[t, y] = ode45(@(t, y) sir_age_model(t, y, parameters), tspan, initial_state_values);
% Plotting the results
plot(t, y);
xlabel('Time (days)');
ylabel('Number of people');
legend('S1', 'I1', 'R1', 'S2', 'I2', 'R2');
title('SIR Model with Age Structure');
What was the cumulative incidence of infection during this epidemic? What proportion of those infections occurred in children?
In the SIR model, the cumulative incidence of infection is simply the decline in susceptibility.
% Assuming 'y' contains the simulation results from the ode45 function
% and 't' contains the time points
% Total cumulative incidence
total_cumulative_incidence = (y(1,1) - y(end,1)) + (y(1,4) - y(end,4));
fprintf('Total cumulative incidence: %f\n', total_cumulative_incidence);
% Cumulative incidence in children
cumulative_incidence_children = (y(1,1) - y(end,1));
% Proportion of infections in children
proportion_infections_children = cumulative_incidence_children / total_cumulative_incidence;
fprintf('Proportion of infections in children: %f\n', proportion_infections_children);
927,447 people became infected during this epidemic, 20.5% of which were children.
Which age group was most affected by the epidemic?
To answer this, we can calculate the proportion of children and adults that became infected.
% Assuming 'y' contains the simulation results from the ode45 function
% and 't' contains the time points
% Proportion of children that became infected
initial_children = 200000; % initial number of susceptible children
final_susceptible_children = y(end,1); % final number of susceptible children
proportion_infected_children = (initial_children - final_susceptible_children) / initial_children;
fprintf('Proportion of children that became infected: %f\n', proportion_infected_children);
% Proportion of adults that became infected
initial_adults = 800000; % initial number of susceptible adults
final_susceptible_adults = y(end,4); % final number of susceptible adults
proportion_infected_adults = (initial_adults - final_susceptible_adults) / initial_adults;
fprintf('Proportion of adults that became infected: %f\n', proportion_infected_adults);
Throughout this epidemic, 95% of all children and 92% of all adults were infected. Children were therefore slightly more affected in proportion to their population size, even though the majority of infections occurred in adults.
Are you going to be in the path of totality? How can you predict, track, and simulate the solar eclipse using MATLAB?
I would like to propose the creation of MATLAB EduHub, a dedicated channel within the MathWorks community where educators, students, and professionals can share and access a wealth of educational material that utilizes MATLAB. This platform would act as a central repository for articles, teaching notes, and interactive learning modules that integrate MATLAB into the teaching and learning of various scientific fields.
Key Features:
1. Resource Sharing: Users will be able to upload and share their own educational materials, such as articles, tutorials, code snippets, and datasets.
2. Categorization and Search: Materials can be categorized for easy searching by subject area, difficulty level, and MATLAB version..
3. Community Engagement: Features for comments, ratings, and discussions to encourage community interaction.
4. Support for Educators: Special sections for educators to share teaching materials and track engagement.
Benefits:
- Enhanced Educational Experience: The platform will enrich the learning experience through access to quality materials.
- Collaboration and Networking: It will promote collaboration and networking within the MATLAB community.
- Accessibility of Resources: It will make educational materials available to a wider audience.
By establishing MATLAB EduHub, I propose a space where knowledge and experience can be freely shared, enhancing the educational process and the MATLAB community as a whole.
The latest release is pretty much upon us. Official annoucements will be coming soon and the eagle-eyed among you will have started to notice some things shifting around on the MathWorks website as we ready for this.
The pre-release has been available for a while. Maybe you've played with it? I have...I've even been quietly using it to write some of my latest blog posts...and I have several queued up for publication after MathWorks officially drops the release.
At the time of writing, this page points to the pre-release highlights. Prerelease Release Highlights - MATLAB & Simulink (mathworks.com)
What excites you about this release? why?
The stationary solutions of the Klein-Gordon equation refer to solutions that are time-independent, meaning they remain constant over time. For the non-linear Klein-Gordon equation you are discussing:
Stationary solutions arise when the time derivative term, , is zero, meaning the motion of the system does not change over time. This leads to a static differential equation:
This equation describes how particles in the lattice interact with each other and how non-linearity affects the steady state of the system.
The solutions to this equation correspond to the various possible stable equilibrium states of the system, where each represents different static distribution patterns of displacements . The specific form of these stationary solutions depends on the system parameters, such as κ , ω, and β , as well as the initial and boundary conditions of the problem.
To find these solutions in a more specific form, one might need to solve the equation using analytical or numerical methods, considering the different cases that could arise in such a non-linear system.
By interpreting the equation in this way, we can relate the dynamics described by the discrete Klein - Gordon equation to the behavior of DNA molecules within a biological system . This analogy allows us to understand the behavior of DNA in terms of concepts from physics and mathematical modeling .
% Parameters
numBases = 100; % Number of spatial points
omegaD = 0.2; % Common parameter for the equation
% Preallocate the array for the function handles
equations = cell(numBases, 1);
% Initial guess for the solution
initialGuess = 0.01 * ones(numBases, 1);
% Parameter sets for kappa and beta
paramSets = [0.1, 0.05; 0.5, 0.05; 0.1, 0.2];
% Prepare figure for subplot
figure;
set(gcf, 'Position', [100, 100, 1200, 400]); % Set figure size
% Newton-Raphson method parameters
maxIterations = 1000;
tolerance = 1e-10;
% Set options for fsolve to use the 'levenberg-marquardt' algorithm
options = optimoptions('fsolve', 'Algorithm', 'levenberg-marquardt', 'MaxIterations', maxIterations, 'FunctionTolerance', tolerance);
for i = 1:size(paramSets, 1)
kappa = paramSets(i, 1);
beta = paramSets(i, 2);
% Define the equations using a function
for n = 2:numBases-1
equations{n} = @(x) -kappa * (x(n+1) - 2 * x(n) + x(n-1)) - omegaD^2 * (x(n) - beta * x(n)^3);
end
% Boundary conditions with specified fixed values
someFixedValue1 = 10; % Replace with actual value if needed
someFixedValue2 = 10; % Replace with actual value if needed
equations{1} = @(x) x(1) - someFixedValue1;
equations{numBases} = @(x) x(numBases) - someFixedValue2;
% Combine all equations into a single function
F = @(x) cell2mat(cellfun(@(f) f(x), equations, 'UniformOutput', false));
% Solve the system of equations using fsolve with the specified options
x_solution = fsolve(F, initialGuess, options);
norm(F(x_solution))
% Plot the solution in a subplot
subplot(1, 3, i);
plot(x_solution, 'o-', 'LineWidth', 2);
grid on;
xlabel('n', 'FontSize', 12);
ylabel('x[n]', 'FontSize', 12);
title(sprintf('\\kappa = %.2f, \\beta = %.2f', kappa, beta), 'FontSize', 14);
end
% Improve overall aesthetics
sgtitle('Stationary States for Different \kappa and \beta Values', 'FontSize', 16); % Super title for the figure
In the second plot, the elasticity constant κis increased to 0.5, representing a system with greater stiffness . This parameter influences how resistant the system is to deformation, implying that a higher κ makes the system more resilient to changes . By increasing κ, we are essentially tightening the interactions between adjacent units in the model, which could represent, for instance, stronger bonding forces in a physical or biological system .
In the third plot the nonlinearity coefficient β is increased to 0.2 . This adjustment enhances the nonlinear interactions within the system, which can lead to more complex dynamic behaviors, especially in systems exhibiting bifurcations or chaos under certain conditions .