Nanoparticle PBPK model

SimBiology model and code to perform CI and NCA analyses, and optimization using parallel computing.

您现在正在关注此提交

This package contains a physiologically-based pharmacokinetic (PBPK) model, based on a publication by Dong et al. The accompanying code can be used to:
* Calculate confidence intervals on parameter estimates and model predictions (SimBiology functions: sbioparameterci, sbiopredictionci)
* Perform noncompartmental analysis (NCA) on PK datasets, as well as model predictions to obtain clinically relevant parameters (SimBiology function: sbionca)
* Illustrate justifications for using parallel computing such as dealing with out-of-memory simulations and increasing performance by introducing MATLAB functions and how they work in conjunction with SimBiology (MATLAB functions: datastore, parfor, mapreduce)
This model and code were also discussed in the following webinar:
http://www.rosaandco.com/webinars/2017/enabling-qsp-and-pk-pd-workflows-using-simbiology-and-matlab-whats-new
Reference:
Model based on:
"Elucidating the in vivo fate of nanocrystals using a physiologically based pharmacokinetic model: a case study with the anticancer agent SNX-2112”
Dong D et al.
International Journal of Nanomedicine, 2015 Volume 10, 2521-2535.

引用格式

MathWorks SimBiology Team (2026). Nanoparticle PBPK model (https://ww2.mathworks.cn/matlabcentral/fileexchange/64988-nanoparticle-pbpk-model), MATLAB Central File Exchange. 检索时间: .

类别

Help CenterMATLAB Answers 中查找有关 QSP, PKPD, and Systems Biology 的更多信息

一般信息

MATLAB 版本兼容性

  • 兼容任何版本

平台兼容性

  • Windows
  • macOS
  • Linux
社区
SimBiology 社区中有更多文件
版本 已发布 发行说明 Action
1.0.0.0

Updated reference