Biologics PBPK model builder for Matlab SimBiology

版本 5.0.0 (974.2 KB) 作者: Armin Sepp
PBPKassembler.m script allows to build highly adaptable SimBiology-compliant two-pore biologics PBPK models.
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更新 2020/11/2

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Two-pore physiologically-based pharmacokinetics (PBPK) for biologics describes the tissue distribution and elimination kinetics of soluble proteins as a function of their hydrodynamic radius and the physiological properties of the organs.
PBPKassembler is a a collection of scripts that allows rapidly to build and debug highly customizable cross-modality/cross-species biologics PBPK models for SimBiology.

引用格式

Armin Sepp (2026). Biologics PBPK model builder for Matlab SimBiology (https://ww2.mathworks.cn/matlabcentral/fileexchange/82144-biologics-pbpk-model-builder-for-matlab-simbiology), MATLAB Central File Exchange. 检索时间: .

Armin Sepp, Mats Bergström & Marie Davies (2020) Cross-species/cross-modality physiologically based pharmacokinetics for biologics: 89Zr-labelled albumin-binding domain antibody GSK3128349 in humans, mAbs, 12:1, DOI: 10.1080/19420862.2020.1832861 Sepp, A., et al. (2019). "Computer-assembled cross-species/cross-modalities two-pore physiologically based pharmacokinetic model for biologics in mice and rats." Journal of Pharmacokinetics and Pharmacodynamics 46(4): 339-359. https://doi.org/10.1007/s10928-019-09640-9

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5.0.0