Hi Zinnia,
yes, you can administer different doses with different targets at the same time during a simulation. You can do this with sbiosimulate or a SimFunction.
Here is an example with sbiosimulate:
% Create a two compartment model
pkm = PKModelDesign;
pkc= addCompartment(pkm, 'Central', 'DosingType', 'Bolus', ...
'EliminationType', 'linear-clearance', ...
'HasResponseVariable', true);
pkp = addCompartment(pkm, 'Peripheral', 'DosingType', 'Bolus', ...
'EliminationType', 'linear-clearance');
modelObj = pkm.construct;
% Create dose
dC = adddose(modelObj,'DoseC');
dC.Amount = 10;
dC.TargetName = 'Central.Drug_Central';
dP = adddose(modelObj,'DoseP');
dP.Amount = 20;
dP.TargetName = 'Peripheral.Drug_Peripheral';
dP.Interval = 5;
dP.RepeatCount = 1;
% Run Simulation
results = sbiosimulate(modelObj,[dC,dP]);
% Plot result
sbioplot(results);
set(gca, 'XLimitMethod','padded','YLimitMethod','padded');
grid on;
I hope it helps.
Best regards,
Jérémy
