I think you want to plot the symbolic expression x^2+1 (that's what A(2,1) gives you). If that's the case, use fplot()
syms x;
A = [0;1;0;1];
A = A*x^2+A
fplot(A(2,1)) % its default interval is [-5 5].
title('plot of X^2+1')
ylabel('x^2+1')
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