Lowess smoothing at the edge of a dataset

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Hi all,
I am currently trying to use Matlab to replicate a graph produced in Prism. However, it seems that Matlab does something strange when you smooth the data at the edge of a dataset.
Example in Prism:
Example in Matlab:
Notes: The blue line is Lowess smoothed with a window of 10 points and then splined.
Any help with this matter would be HUGELY appreciated. Perhaps Prism has a trick for filling in datapoints on the edge (the first 4 or 5?)
Thank you!

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