You can reshape the matrix to 2D and then when you get results convert it back to the orginal dimensions if needed
There tricky part is to choose how to reshape. But say 2 dimensions are data, and the third is time then
data3d = ones([2,2,3]);
data2d = reshape(data3d,[],size(data3d,3));
size(data2d)
so the columns become the new time dimension.
