help with pharmacokinetic model (enzyme activity and transporter)

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john Chandler 2022-5-19

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回答： john Chandler 2022-5-20

Hi,

I am studying drug pharmacokinetics. I would like to model how enzyme activity (cytochrome p450) and absoprtion would affect the PK profile. I am new to the simbiology and pk/pd modeling. I was loooking through the matlab tutorials but didn't find how these two parameters can be changed. If anyone has insights on how I can create these models, I would appreciate it.

Thanks,

John

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Answer 1

Teerachat Saeheng 2022-5-19

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编辑：Teerachat Saeheng 2022-5-19

Hi John,

Based on my experience, you can change the effect of the CYP450 on the PK profiles by editing the equation in the rules. It depends on where the equations of CYP450 for drug metabolism you write down are. It is also up to the type of data for CYP450 you put in the model, e.g., Vm/Km, and intrinsic clearance (CLint). You can adjust those data to see the effect of the clearance on PK profiles. In addition to the Ka, If you use effective permeability from Caco-2 cells, MDCK cells, or the prediction using HBD, PSA. You can change this information in your equation. Normally, the equations to govern these values are located in the rules.

Hope it would be beneficial for you

Regards,

Teerachat Saeheng