How to fit a hill curve on scatterplot

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Aaron Ouyang
Aaron Ouyang 2022-7-14
评论： Aaron Ouyang 2022-7-15
Hi,
I've been plotting dose-response curves of the concentration of a drug vs. the response. I want to insert a binding curve based on the Hill equation on top of my scatterplot and was wondering how I can fit this curve on my graph. Here's the equation that I've been referring to and I've also been looking into custom matlab functions like this, but I've haven't really had much success. Here's my code and graph:
scatter(conc_nm_5ht,resp_conc_5ht)
set(gca, 'XScale', 'log')
Thanks!

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回答（1 个）

Rishita
Rishita 2022-7-15
mx = 0;
mn = 1;
ec50 = 0.25;
n=5;
x=0:.01:1;
y = mn + (mx-mn)*ec50^n./(ec50^n+x.^n);
plot(x,y)
grid on
Try this
  1 个评论
Aaron Ouyang
Aaron Ouyang 2022-7-15
Thanks.
That generates a generic sigmoidal curve. How can I get it to fit my data specifically though?

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