What has this to do with MATLAB?
The axis has NOTHING to do with the slope!!!!
The slope in both cases is (y2 - y1)/(x2 - x1). Which axis a line intersects is completely irrelevant. In fact, do you see the line ALWAYS intersects both axes, unless the line is exactly horizontal or vertical. In the case of a vertical line of course, the slope is undefined.
How you define the ANGLE a line intersects with an axis is irrelevant, as slope is not represented by an angle. Yes, you can compute that angle, but then surely you would recognize that the angle a line makes when it intersects with the two axes is always given by the angles of a right triangle, and therefore one angle is 90 degrees minus the other?