Hi Caleb,
The message indicates that there is a permanent opening in the architecture of your model. i.e. an open circuit path.
As long as the opening persists, the model will not be able to run and henceforth, this needs to be closed.
You might need to individually go through all blocks and subsystem blocks to check if one of the blocks is not connected to the other i.e. a block whose inputs or outputs are not connected, or a block with an open input or output port that is not being used. You will need to connect this block or delete it if its not in use, that would help close the circuit.
Thanks