Question about available PK models for practicing purposes

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Christos 2022-11-18

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评论： Christos 2022-11-18

Hi all,

I have a question about SimBiology and PK models. Are there available any "simple", models for practicing, say a single- or 2-compartment model where one could plug-in PK parameter values and simulate a hypothetical drug? If not, is this something that the SimBiology community would like to distribute to other people who are beginners? This would be helpful to develop a feeling as to how a model behaves and reacts based on different PK parameter values and sometimes save time even. My colleagues and I would like to learn SimBiology for more advanced PK modeling but we thought that it would be more efficient if we could use a pre-developed one and adjust values etc. Videos and documentations are great but a hands-on example model would also be extremely helpful.

Thank you for your time!

Best regards,

Christos

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Answer 1

Fulden Buyukozturk 2022-11-18

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Hi Christos,

A couple of thoughts:

SimBiolog has a PK library. You can pick a 1 or 2 comp model from there, populate the parameter values/dosing and run. If you're running using Model Builder app, you can go Home->Model->Load model from PK library. If you're running from the command-line interface, please see this page.
There are multiple example SimBiology models in the community site with associated publication references.

Hope these help you get started, please let me know.

Fulden