running sbiosteadystate before each simulation in a fit is not supported.
That said, I see two options:
- If your case is simple enough, you might be able to express the species concentrations at time=0 as a function of parameters: e.g. receptor = ksyn/kdeg. I understand it might not be feasible though.
- You could shift the times in your data to fit by an offset large enough to reach steady state before the first dose is applied. To shift the time vector, you can add a derived column to the dataset in Model Analyzer and define it as the independent variable. For example:
Best regards,
Jérémy
