Simbiology program code gave different results from my custom code
显示 更早的评论
Hello team,
I am working on a population pharmacokinetics (PK) project, so I am using sbiofitmixed() to solve the model.
However, I found that the fit program code directly exported from Simbiology Model Analyzer gave me different results from my custom code. Although I have all the settings set as the same, I have a problem with the parameter estimation on ka_Central.
My Simbiology Model Analyzer code can estimate this parameter with high confidence, but my custom code cannot.
I tried debugging but could not find where the problem came from.
Please find the code in the attachment file.
Thank you very much.
Jesse
采纳的回答
Jeremy Huard
2023-5-25
1 个投票
the issue comes from the dose template. In the first version your taget is Drug_Central (corresponding to IV bolus) whereas in the second the tdrug target is Dose_Central (corresponding to EV).
Since no absoprtion takes place in the first version, ka cannot be estimated.
If you change the drug target to Dose_Central, you will be able to estimate ka.
Best,
Jérémy
更多回答（1 个）
Jeremy Huard
2023-5-25
0 个投票
this is difficult to debug without the actual model and data.
Would you be able to share them?
That said, I noticed a discrepancy in the initial values of both versions because of the order of estimated parameters (ka, Central, CL) instead of (ka, CL, Central).
Best,
Jérémy
社区
更多回答在 SimBiology Community
类别
在 帮助中心 和 File Exchange 中查找有关 Import Data 的更多信息
Community Treasure Hunt
Find the treasures in MATLAB Central and discover how the community can help you!
Start Hunting!
Translated by 
