How to simulate multiple doses and generate only one plot?

Question

Lo 2023-9-13

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https://ww2.mathworks.cn/matlabcentral/answers/2020176-how-to-simulate-multiple-doses-and-generate-only-one-plot

评论： Sam Chak 2023-9-16

I want to try many dosages of one species and generate only one plot. So I wonder if simbiology has such a function or if I need to use another Matlab tool.

the plot is like this:

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Answer 1

Bhargavi Srija Ramisetty 2023-9-13

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Hi Lo,

I believe you can use repeat dosing feature in simbiology.

Best

Srija

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Answer 2

Sam Chak 2023-9-13

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在 MATLAB Online 中打开

Hi @Lo

Are you looking to plot something like this?

m1 = sbiomodel('onecomp');

r1 = addreaction(m1,'drug -> null');

k1 = addkineticlaw(r1,'MassAction');

p1 = addparameter(k1,'ke','Value',1.0,'ValueUnits','1/hour');

k1.ParameterVariableNames = 'ke';

r2 = addreaction(m1,'dose -> drug');

k2 = addkineticlaw(r2,'MassAction');

p2 = addparameter(k2,'ka','Value',0.1,'ValueUnits','1/hour');

k2.ParameterVariableNames = 'ka';

amt = [250 500]; % dosage amount

for j = 1:numel(amt)

d1 = sbiodose('d1','repeat');

d1.Amount = amt(j);

d1.AmountUnits = 'milligram';

d1.Interval = 8;

d1.TimeUnits = 'hour';

d1.RepeatCount = 5;

d1.Active = true;

d1.TargetName = 'dose';

cs = getconfigset(m1);

cs.StopTime = 48;

cs.TimeUnits = 'hour';

cs.RuntimeOptions.StatesToLog = {'drug'}; % comment out this line if want to plot dosage

[t, sd, species] = sbiosimulate(m1,d1);

plot(t, sd), hold on

end

hold off, grid on

legend('250 mg', '500 mg', 'Location', 'NW');

xlabel('Hours');

ylabel('Drug Concentration');

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Lo 2023-9-13

hi Sam Chak

I'm not very familiar with program. could you please show me in diagram form ? thank you !

best

Eric

Sam Chak 2023-9-16

Hi @Lo,

I believe you might be referring to the SimBiology Model Analyzer app, which offers a user-friendly graphical interface for entering data and performing actions with just a few clicks. You can find useful information and examples on this page:

https://www.mathworks.com/help/simbio/simbiology-apps.html

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