One approach would be to create a 2x1 tiledlayout where inside each tile you nest another tiledlayout of dimension 2x6. You can facilitate this by downloading nestedLayouts() from the File Exchange,
Example:
[ax,t,T]=nestedLayouts([2,1],[2,6]);
for i=1:numel(ax) %populate all 24 axes with plot data
plot(ax(i),rand(1,5));
end
for i=1:numel(t) %Give each outer tile its own ylabel
ylabel(t(i),"ylabel No. "+i);
end
