Hi @Yasaswi
You can easily work with Excel files and solve optimization problems in MATLAB. Start by importing your Excel data using the readtable function. Check out how to use it here.
Next, define your optimization problem in MATLAB. Create a function for your objective that takes a vector of variables and returns your objective metric. For non-linear constraints, define separate functions for the constraint values and gradients.
For solving non-linear optimization, MATLAB offers various solvers. Explore the solver-based nonlinear optimization documentation here for functions and examples that can help. A good starting example is this fmincon solver guide.
Hope this helps!