Oral Dose Not Exhibiting Absorption​/Bioavaila​bility in Simulation

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grace
grace 2024-8-13
回答： Arthur Goldsipe 2024-8-14
Hello! I am trying to use this model "Estimating the Bioavailibility of a Drug" that I found here, to do a simultaneous fitting of my IV infusion and P.O. blood concentration time profile. I implemented a two compartment model as well. For some reason, when I am running a simulation the oral dose exhibits a bioavailbility of >= 1, even though I have the parameter F set as 0.2. I attached images of my simulation curve (green is oral dose), model diagram, ODEs, and dosing setup. I'm thinking it might have something to do with the way I set up the dosing, but please let me know if you have any advice on how I should troubleshoot this. I am using R2024a. Please let me know if I should include anything else. Thanks!
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grace
grace 2024-8-13
Just wanted to update that I figured out a solution to the problem! I ended up creating a new species called Drug_Infusion in the Blood compartment and assigning the Infusion dose to that species. Then i used the Drug_Central in the Blood compartment for simulation of the oral dose, and Drug_infusion for the simulation of the Infusion dose. It ended up solving the issue I was having with the starting value of the oral dose being 4.5x10^5! Thanks a lot for your help.
Arthur Goldsipe
Arthur Goldsipe 2024-8-14
Excellent. I'm just going to copy that into the answers section, so that it's clear this question has been answered.

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Arthur Goldsipe
Arthur Goldsipe 2024-8-14
Copying the answer from the comments: "Just wanted to update that I figured out a solution to the problem! I ended up creating a new species called Drug_Infusion in the Blood compartment and assigning the Infusion dose to that species. Then i used the Drug_Central in the Blood compartment for simulation of the oral dose, and Drug_infusion for the simulation of the Infusion dose. It ended up solving the issue I was having with the starting value of the oral dose being 4.5x10^5! Thanks a lot for your help."

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