Why are population estimated parameters values the same as individual estimated parameters values?

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Day 2024-9-27
回答： Arthur Goldsipe 2024-9-27
Hi,
I good patients data. I did population fit 'mixed effect'. The fits for individual patients were very good but the population fit was not good for a few parameters. How could I solve that?
Also, for a few parameters, the population estimated parameters values were the same as individual estimated parameters values. I don't know why did that happen. How could I solve that?
Thank you.

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回答（1 个）

Arthur Goldsipe
Arthur Goldsipe 2024-9-27
Without the actual project, it's difficult to say what's going on. So let me offer some potential explanations for what you're seeing:
  • Your model might be incapable of fitting the data for some of the patients.
  • Your data might be insufficient for identifying some of the parameters
  • The simulation results might be insensitive to some of the parameters.
If you can share your project (publicly or privately), then we could probably offer a more definitive answer.

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