The following example from the MathWorks File Exchange can assist in getting started with modeling disease spread using an SEIR model in MATLAB
The overall structure of the code should resemble the following:
% Define Model & Fitness Function
net = feedforwardnet([10, 10]);
fitnessFunction = @(params) evaluateModel(params, net, data);
% Run GA
[bestParams, fval] = ga(fitnessFunction, ...);
options = optimoptions('fmincon', 'Algorithm', 'sqp');
% Run SQP
[refinedParams, fval] = fmincon(fitnessFunction, bestParams, ...);
Hope this helps you.
