In times gone by it was possible to speed up your simulation simply by running on a bigger or newer machine but those days have largely gone except for a few edge cases. The answer to your question depends hugely on the details of your simulation and when I say 'details' I don't just mean 'Is it MATLAB or Simulink you are using?' I mean 'You would need to share your code to get a meaningful answer'.
There is no simple congifuration change that can be made to speed-up all code on a given machine. If there was, MATLAB would already do it by default.
If you can't share your code, and assuming it is MATLAB you are using, I would suggest starting with the MATLAB profiler to see what is taking so much time. Here's a video on how to use the profiler MATLAB Profiler with Flame Graph
