Initial conditions in the Population PKPD model of human physiology data

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Andy
Andy 2015-9-14
编辑： Andy 2015-9-14
How can I create a Population PKPD Model with an Epinephrine Infusion that has Initial Conditions as a Covariate or set to the values at time=0. This is due to the body already has endogenous epinephrine levels.
Also, I would like to have the PD portion, which would be Cardiac Output (would increase during infusion) or Systemic Vascular Resistance (would decrease during infusion).
Then I would like to add a categorical covariate as a gender or genotype.
Thank you for help with creating this model.
Sincerely, Andy

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