How to use PCA to perform a mesh optimization?

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I have data of several 3d vertebra structures, I calculate parameters as: Thickness, Connectivity and Space distance using Bonej on several regions of interest (ROI). I Calculate PCA model of those parameters and ROI.
If I select randomly one of those ROI, how I can use my PCA model to perform a mesh optimization or simplification of the ROI selected?
Thank you

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