Use the vpa function:
syms L F q
Eqn = (1.346491*q*(L^2)^(7/2))/(L^5*abs(L)) - 0.1559454*F;
Simplified_Eqn = vpa(simplify(Eqn, 'Steps',10))
Simplified_Eqn =
1.3464910000000001044639930114499*L*q - 0.15594540000000001178648290078854*F
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