SimBiology Parameter Estimation: How to use 2 different data sets to generate parameters?

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Jonathan Hamp
Jonathan Hamp 2016-11-26
回答： Arthur Goldsipe 2016-11-28
I have a multi-compartmental PK model that I am trying to parameterise utilising two different data-sets.
One data-set is a short term data set (0 -> 24hrs) and the second data set is a single data point at 168 hrs. The only difference between the two is that the initial bolus dosage is a different amount (and so I cannot combine the two sets)
How can I get SimBiology to run a parameter estimation where the output parameters are based off of both data sets?
I am running MATLAB R2016b on Mac & Version 5.5 of SimBiology

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Arthur Goldsipe
Arthur Goldsipe 2016-11-28
Hi Jonathan,
SimBiology supports this sort of task (estimating a single set of model parameters by simultaneously fitting a model to multiple time courses).
You can do this from the command line using the sbiofit command with the option Pooled set to true. You can find an example of that here. You can also accomplish this from a Fit Data Task in the SimBiology Desktop, by checking the box labeled "Pool data" in the Estimation Method section of the task. You can find a bit more information about the Fit Data Task here.
Good luck,
Arthur

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