How are you going to feed it that information? There are several Toolboxes that would be useful, such as the Data Acquisition Toolbox, Mapping Toolbox and others. See the Help Index for the documentation for these and other Toolboxes. That will help you decide what you need.
As for writing the code to predict the landing, you would have to write your own software for that. Since I’ve not worked with weather balloons or their aerodynamics, I would need to know more about the details of what you want to do to help you.
I would search the Interweb for relevant information. For example, MATLAB code for Weather Balloon Physics is available on this link. Dr. Kelly Kearney, who knows everything there is to know about the Mapping Toolbox and marine ecosystems, provided an Accepted Answer to a relevant weather balloon Question here in How can I see matlab results on google earth? These may also provide you with information based on what others have already done.
Post back here if you need help. You will probably have to explain weather balloons to us, but we can help with the coding.
